4th June,1999 Dear Dr. Dang Bingrong: Mental activities of human beings, such as cognition and so on, rely mainly on the functions of human brain. Human cerebrum has some 1 500 hundred million cells, only 1%-1.5% of them really participate in functional activities of the brain, that is, only 15-22 hundred million cells participate in functional activities of the brain. Cells participating in functional activities of the brain, the so-called kinetocytes, refer to a nerve cell connected with another nerve cell by a nerve bond to make a return circuit of nerve of cerebral bio-electricity and transmission of neurotransmitter. Only such cells have activity; otherwise, they are in dormant state. The amount of kinetocytes in the brain of everybody determines his intelligence and the function of central nervous system. Insufficient quantity of kinetocytes in the brain may also give rise to dysfunction of nerve path, nerve conduction and dopaminergic and cholinergic nerve. In infants and young children the insufficient quantity of kinetocytes will undoubtedly lead to disturbance of intelligence, aphasis, dyskinesia, dysopia and dysaudia. The reason why human beings have speech and creative
Delicate brain cells, especially those of cerebral cortex, cannot withstand severe or long-term ischemia or anoxia. Your child's illness is brain injury caused by anoxia due to perinatal suffocation which then proceeds to developmental retardation of central nervous system. So it is not strange for a child aged 1 year and 9 months not to walk, not to speak, not to use hands, not to look attentively at objects and to have convulsions. He should be diagnosed as having mental retardation caused by suffocative anoxia complicated with cerebral palsy, disturbance of linguistic function and epilepsy. It is still necessary to make a fundus examination to define the presence of optic atrophy or cortical blindness. The first step of treatment is to improve the metabolism of brain cells, to increase the activities and functions of the existing brain cells with drugs, then to activate the dormant brain cells by synaptic contact of nerves and gradually to constitute a network of nerves extremely complex in structure and high-potency in function. The medical practice of several ten thousand cases has demonstrated that the prescription of Chinese drugs we used does have the effect of promoting intelligence and improving dysfunction of nerve. Experimental studies have also showed that Li's Prescription No.5 does promote proliferation of nerve cells, the proliferation rate being 63.9% and that it inhibits the apoptosis of nerve cells under ischemic or anoxic state, the inhibition rate being as high as 93%. It is evident that Li's Prescription No.5 does improve the metabolic course of brain cells. Your child can be given oral administration of Li's Prescription No.5 Capsule, three times a day, two capsules each time. On the basis of pharmacotherapy such rehabilitation trainings as motor and speech training should be given. In the case of your child, passive movement and massage should be taken as the dominant training, he should be trained to creep, to hold a thing with hands. He should be given patient and scientific speech training and taught to listen to speech and to music and to pronounce. Children are the flowers and future of our country. Pregnant women are
to pay great attention to the health of themselves, to avoid falling ill
as far as possible, to take as fewer medicines as possible and to avoid
contacting such noxious factors as rays, tobacco and wine. Obstetricians
and gynecologists and pediatricians should pay even better attention to
the health of parturients and their offsprings, do all they can to reduce
suffocation, anoxia, infection and trauma and give prompt effective treatment
of nuclear icterus and hereditary metabolic disease. Every effort should
be made to reduce the development of various diseases that affect the
functioning of the brain and to raise the therapeutic level of encephalopathy.
Sincerely yours, Li Zizhong
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